Novel Size-Variable Dedicated Rodent Oxygenator for ECLS Animal Models—Introduction of the “RatOx” Oxygenator and Preliminary In Vitro Results

The overall survival rate of extracorporeal life support (ECLS) remains at 60%. Research and development has been slow, in part due to the lack sophisticated experimental models. This publication introduces a dedicated rodent oxygenator (“RatOx”) presents preliminary vitro classification tests. RatOx an adaptable fiber module size for various Gas transfer performances over different blood flows sizes were tested according DIN EN ISO 7199. At maximum possible amount effective surface area flow 100 mL/min, performance was 6.27 mL O2/min 8.2 CO2/min, respectively. priming volume largest is 5.4 mL, while smallest configuration with single mat layer 1.1 mL. novel ECLS system evaluated demonstrated high degree compliance all pre-defined functional criteria rodent-sized animal We intend become standard testing platform scientific studies on therapy technology.